Volume Overload Influence on Hypertrophied Myocardium Function.
نویسندگان
چکیده
منابع مشابه
Volume overload influence on hypertrophied myocardium function.
The aim of this study was to demonstrate that hypertrophied cardiac muscle is more sensitive to volume-overload than normal cardiac muscle. We assessed the mechanical function of isolated left ventricular papillary muscle from male spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY) submitted to volume overload caused by aortocaval fistula (ACF) for 30 day...
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CARDIAC REMODELING has been described as both an adaptive and a maladaptive process. The adaptive component enables the heart to maintain function in response to pressure overload and has the effect of decreasing ventricular wall stress and compensates for the increased workload preserving cardiac function. Along with the changes in ventricular mechanics, the development of hypertrophy is accom...
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Because the left ventricular (LV) hypertrophy due to volume overload induced by arteriovenous (AV) shunt was associated with an increase in phospholipase C (PLC) isozyme mRNA levels, PLC is considered to be involved in the development of cardiac hypertrophy. Since the renin-angiotensin system (RAS) is activated in cardiac hypertrophy, the role of RAS in the stimulation of PLC isozyme gene expre...
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Left ventricular hypertrophy (LVH) is due to pressure overload or mechanical stretch and is thought to be associated with remodeling of gap-junctions. We investigated whether the expression of connexin 43 (Cx43) is altered in humans in response to different degrees of LVH. The expression of Cx43 was analyzed by quantitative polymerase chain reaction, Western blot analysis and immunohistochemist...
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ژورنال
عنوان ژورنال: Japanese Heart Journal
سال: 2002
ISSN: 0021-4868,1348-673X
DOI: 10.1536/jhj.43.689